Principal cell types of sleep–wake regulatory circuits

Publication date: June 2017
Source:Current Opinion in Neurobiology, Volume 44
Author(s): Barbara E Jones
Electrophysiological recordings indicate that neurons which discharge maximally in association with distinct sleep–wake states are distributed through the brain, albeit in differing proportions. As studied using juxtacellular recording and labeling within the basal forebrain, four functional principal cell types are distinguished as: wake/paradoxical sleep (W/PS)-, slow wave sleep (SWS)-, W- and PS-max active. They are each comprised by both GABA and glutamate neurons, in addition to acetylcholine neurons belonging to the W/PS group. By their discharge profiles and interactions, the GABA and glutamate neurons of different groups are proposed to have the capacity to generate sleep–wake states with associated EEG and EMG activities, though to also be importantly regulated by neuromodulatory systems, each of which belong to one functional cell group.



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