Promotion of oral surgical wound healing using autologous mucosal cell sheets

Oral mucosal and soft tissue defects can be caused by surgical extirpation of intraoral pathological lesions, trauma, recurrent ulcers, and irradiation. If not properly treated, the defects lead to pain, infection, and later undesirable healing, such as scarring and adhesion to adjacent tissues. This might cause significant deficits of functions that are essential for daily life, such as deglutition, articulation, and speech, as well as respiration. To prevent undesirable discomfort and sequelae, a skin graft, local or regional flap, or microvascular free flap is currently used to restore the mucosal lining or soft tissue defects in the oral cavity.

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