Reply

I thank Giorgio Ciprandi1 for commenting on my recent article2 and for proposing, on the basis of results of reports cited in his letter, that serum levels of allergen-specific IgE (sIgE) could be considered a potential biomarker to identify those patients with allergic rhinitis most likely to respond to allergen-specific immunotherapy (SIT). Specifically, Ciprandi highlighted articles reporting that subjects with allergic rhinitis whose blood sIgE level exceeded specified amounts were much more likely to respond to SIT than those with lower levels of sIgE; he also cited 1 article reporting conflicting results.

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