Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide.

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Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide.

J Pediatr Endocrinol Metab. 2016 Dec 01;29(12):1413-1415

Authors: Felker J, Patterson B, Wrubel D, Janss A

Abstract
Prolactinomas are a rare subset of brain tumors in pediatrics. We report a child with a prolactin secreting macroadenoma which was refractory to initial treatment with a dopamine antagonist. Given the location of her tumor she was ineligible for surgical resection. Temozolomide (200 mg/m2×5 days each month) was administered with a dramatic and prolonged response in tumor size, prolactin level, and symptoms, with no side effects from treatment. We demonstrate the benefit of temozolomide in the treatment of a pediatric patient with prolactinoma.

PMID: 27815961 [PubMed - indexed for MEDLINE]

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