Successful treatment of Rosai–Dorfman disease using in situ photoimmunotherapy

Meng Li, Lei Shi, Min Luo, Jia Chen, Bo Wang, Fuhe Zhang, Uma Keyal, Anil Kumar Bhatta, Wei R Chen, Xiuli Wang

Indian Journal of Dermatology, Venereology, and Leprology 2017 83(3):332-336

Rosai–Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai–Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai–Dorfman disease.

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