Systemic reaction to timothy grass pollen sublingual immunotherapy

Allergen immunotherapy is an effective way of treating allergic rhinitis and allergic asthma. It can be performed by sublingual or subcutaneous administration of allergens. Currently, tablet formulations have been approved in the United States for grass pollen and ragweed pollen.1 Even though sublingual immunotherapy (SLIT) has a better safety profile than subcutaneous immunotherapy (SCIT) with mostly local reactions, there is a risk of systemic reaction that must be considered.1 This case report discusses a systemic reaction to timothy grass (Phleum pratense) pollen tablets.

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