The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design

Publication date: 25 April 2017
Source:Cell Reports, Volume 19, Issue 4
Author(s): Christina Beatrice Karsten, Galit Alter
Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.

Teaser

Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.


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