A case of adult onset Langerhans cell histiocytosis with neurodegenerative central nervous system disease

A 75-year-old woman presented with 2-year history of persistent pruritic dermatitis on her trunk. She had been treated by topical corticosteroids without improvement. Around the same time, she felt numbness on her face, and became unsteady on her feet. She also had appetite loss and sick feelings, with 5-kg weight loss in 9 months. As there were no abnormal findings with endoscopy and blood tests, she had been treated as dysautonomia. According to her family, she seems to have personality change.

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