Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment.

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Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment.

Biomed Rep. 2017 May;6(5):545-548

Authors: Sonnenblick A, Zahavi T

Abstract
The long-term prognosis following resection of hepatocellular carcinoma (HCC) remains unsatisfactory as a result of a high incidence of recurrence. Prevention of recurrence is the most important strategy to improve the long-term survival results. The role of hepatectomy itself, as an accelerator of carcinogenesis, has not been adequately evaluated in HCC patients. Studies in animal models have revealed a link between liver regeneration under chronic inflammation and hepatic tumorigenesis. Inhibiting different signal transduction pathways during liver regeneration without compromising the ability of the liver to regenerate appears to be a rational strategy and may decrease HCC development and recurrence. If this hypothesis is proven using animal models, this strategy could be evaluated in future clinical trials in humans.

PMID: 28515912 [PubMed - in process]

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