Analysis of prognostic factors, survival rates and treatment in anaplastic hemangiopericytoma.

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Analysis of prognostic factors, survival rates and treatment in anaplastic hemangiopericytoma.

World Neurosurg. 2017 May 25;:

Authors: Zhang GJ, Zhang LW, Li D, Wu Z, Zhang JT

Abstract
OBJECTIVE: In this study, we aimed to identify prognostic factors in anaplastic hemangiopericytoma (AHPC) and clinical behaviors that differentiate primary and secondary AHPC.
METHODS: The clinical data associated with 52 cases of AHPC that were surgically treated between 2008 and 2015 were reviewed. The patients were classified into the following 2 groups: primary AHPC (AHPC diagnosed at the first surgery) and secondary AHPC (malignant transformation from a lower-grade tumor).
RESULTS: The study included 27 men and 25 women. The participants had a mean age of 43 years old. The 3- and 5-year progression-free survival (PFS) rates were 63.4% and 53.5%, respectively, and the corresponding overall survival (OS) rates were 78.7% and 70.9%, respectively. At the final follow-up, there were 22(42.3%) recurrences, 4 (7.7%) extra-cranial metastases, and 11 (21.2%) deaths. Based on a multivariate analysis, primary AHPC (HR=0.293, 95% CI 0.122-0.705) and postoperative radiotherapy (PRT)(HR=0.372, 95% CI 0.148-0.932; P=0.035) were significantly associated with increased PFS, and gross total resection (GTR)(HR=3.512, 95% CI 1.060-11.634; P=0.040) and PRT (HR=0.165, 95% CI 0.035-0.771; P=0.022) were independent favorable factors for OS.
CONCLUSION: GTR and PRT following surgery are recommended in AHPC. Identifying clinical behaviors that differentiate primary and secondary AHPC improved our understanding of this type of tumor and guided treatment strategies.

PMID: 28552736 [PubMed - as supplied by publisher]

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