Frequency of untreated hypogammaglobulinemia in bronchiectasis

Bronchiectasis is found in approximately one fourth of patients with common variable immune deficiency, with 14% in 1 study having bronchiectasis at the time of diagnosis,1 and lower respiratory tract symptoms are associated with a lower quality of life and require increased immunoglobulin (Ig) usage.2,3 Additional primary immune deficiencies also are associated with a high rate of bronchiectasis, including IgA deficiency, IgG subclass deficiency, and specific antibody deficiency against polysaccharide antigen despite normal levels of quantitative immunoglobulins.

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