Influence of FLG mutations and TSLP polymorphisms on atopic dermatitis onset age

Atopic dermatitis (AD) is a chronic, inflammatory skin disorder driven by complex biologic and environmental influences. AD has been divided into early-onset and late-onset forms, with some speculating that early-onset AD is driven predominantly by genetic factors, whereas late-onset disease is driven by environmental exposures.1 Among many genetic factors relevant to AD are filaggrin (FLG), an epidermal barrier protein, and thymic stromal lymphopoietin (TSLP), an interleukin 7–like cytokine that promotes TH2 cell differentiation.

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