Pax2: A “Keep to the Path” Sign on Waddington’s Epigenetic Landscape

Publication date: 22 May 2017
Source:Developmental Cell, Volume 41, Issue 4
Author(s): Jamie Davies
Developing kidneys have Foxd1⁺ stromogenic stem cells and [Six2⁺, Pax2⁺] nephrogenic stem cells. In this issue of Developmental Cell, Naiman et al. (2017) show that targeted Pax2 deletion converts nephrogenic cells to the stromogenic path, suggesting that Pax2 normally represses an otherwise inevitable transition between sister lineages.

Teaser

Developing kidneys have Foxd1⁺ stromogenic stem cells and [Six2⁺, Pax2⁺] nephrogenic stem cells. In this issue of Developmental Cell, Naiman et al. (2017) show that targeted Pax2 deletion converts nephrogenic cells to the stromogenic path, suggesting that Pax2 normally represses an otherwise inevitable transition between sister lineages.


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