The IL-33/ST2 axis is crucial in type 2 airway responses induced by the Staphylococcus aureus protease SplD

S.aureus protein SplD acts as an allergen and an adjuvant inducing asthma features via inducing IL-33 production by airway epithelial cells. Soluble IL-33 receptor is a promising treatment option as it interferes with SplD-induced inflammation.

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