B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation

Maternal allergen application before conception protects murine WT-offspring from allergy but aggravates allergic airway inflammation in B-cell deficient pups. Perinatal tolerance induction is associated with intrauterine antigen/IgG-transfer to fetal DCs which in turn effectively prime antigen-specific Tregs.

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