Epithelial perviousness in allergic airways disease

Löser et al1 infer that increased airway surface albumin in their mouse model of asthma reflects defect epithelial integrity. A defect epithelial barrier in asthma, letting through allergens and other inhaled disease-inducing factors, is an established paradigm.2 However, 2 aspects seem forgotten: (1) The asymmetry of the epithelial barrier operating such that microvascular-epithelial exudation of plasma macromolecules occurs without increased passage of molecules in the opposite direction. (2) Late 1900 work demonstrating that bronchial epithelial permeability in asthma is not increased.

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