For Certain, SIRT4 Activities!

Publication date: Available online 3 June 2017
Source:Trends in Biochemical Sciences
Author(s): Surinder Kumar, David B. Lombard
Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.



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