Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy

International Journal of Radiation Oncology, Biology, Physics, Volume 98, Issue 5, 2017 Aug 1 | Mistry, Ishna N., PhD; Thomas, Matthew, BA; Calder, Ewen D.D., PhD;...
Introduction Regions of low oxygen (hypoxia) arising from an imbalance in cellular oxygen demand and availability are a common feature of solid tumors. Both diffusion and perfusion limitations contribute to the prevalence of hypoxia in solid tumor...

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