Prognostic value of the eighth edition AJCC TNM classification for differentiated thyroid carcinoma

The American Joint Committee on Cancer (AJCC) tumor, node, and metastasis (TNM) system is the most widely used indicator of cancer mortality in patients with differentiated thyroid carcinoma (DTC) [1,2]. Unlike most malignancies, age at diagnosis is almost always identified as an independent predictor of cancer mortality in DTC. Accordingly, the TNM system of DTC has incorporated both anatomic and nonanatomic (an age cutoff of 45years) prognostic factors since its second edition was published in 1983 [3].

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