Large nose angiosarcoma treated effectively with oral cyclophosphamide combined with propranolol

Abstract

Angiosarcomas are rare soft-tissue tumors of endothelial cell origin. They are associated with high rates of local recurrence and poor prognosis¹. The standard of care for cutaneous angiosarcomas is surgical excision. In some cases, surgery is not possible because too mutilating. In these indications, only few chemotherapeutic drugs are available, i.e.paclitaxel or doxorubicin (with a progression-free survival (PFS) of 3.7-5.4 months for doxorubicin²).

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