Neutralization of interferon-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome

In a murine model of MAS, the IFNγ pathway is activated and has a pathogenic role, as neutralization of IFNγ reverts the disease. These results provide the rationale for the therapeutic targeting of IFNγ in MAS.

http://ift.tt/2vQlYNQ