Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy

Locally advanced oral cavity squamous cell carcinoma (OCSCC) is standardly treated with surgery. Adjuvant postoperative radiation therapy is recommended for patients with adverse features including: stage IV disease, inadequate margins, and invasion of tumor into perineural spaces, lymphovascular spaces or bone. Over the last decade, the addition of chemotherapy to adjuvant radiation was recommended, particularly for patients who have 'high risk' pathologic features which include extracapsular nodal extension (ECE) and/or a positive surgical margin.

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