Rebamipide gargle in preventive management of chemo-radiotherapy induced oral mucositis

Oral mucositis is inflammation of oral mucosa which is an inevitable and acute side effect in patients undergoing chemo-radiotherapy for head & neck cancer. The clinical appearance ranges from redness to severe ulceration causing pain that is aggravated even by normal oral functioning [1]. The extent of the injury is directly related to the mucosal volume irradiated, anatomic sub site exposed, treatment intensity, and individual patient predisposition [2]. Oral epithelial basal cells have high mitotic rate, thus they are commonly affected by cytotoxic drugs and ionizing radiation.

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