Zika virus (ZIKV), a single-strand RNA virus from the Flaviviridae family, has been a major worldwide public health problem primarily because of its association with congenital defects and Guillain-Barré syndrome. The ZIKV infection was first identified in Uganda in 1947. Since the description of the endemic transmission in South and Central America in 2015, travel-associated cases have been reported in every state of the United States, except for Alaska, with locally acquired cases reported in Texas and Florida.
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