Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis

Publication date: November 2017
Source:Biomedicine & Pharmacotherapy, Volume 95
Author(s): Zubair Shanib Bhat, Muzafar Ahmad Rather, Mubashir Maqbool, Hafiz UL Lah, Syed Khalid Yousuf, Zahoor Ahmad
Tuberculosis is the leading infectious disease responsible for an estimated one and a half million human deaths each year around the globe. HIV-TB coinfection and rapid increase in the emergence of drug resistant forms of TB is a dangerous scenario. This underlines the urgent need for new drugs with novel mechanism of action. A plethora of literature exist that highlight the importance of enzymes involved in the biosynthesis of mycobacterial cell wall responsible for its survival, growth, permeability, virulence and resistance to antibiotics. Therefore, assembly of cell wall components is an attractive target for the development of chemotherapeutics against Mycobacterium tuberculosis. The aim of this review is to highlight novel sets of enzyme inhibitors that disrupt its cell wall biosynthetic pathway. These include the currently approved first and second line drugs, candidates in clinical trials and current structure activity guided endeavors of scientific community to identify new potent inhibitors with least cytotoxicity and better efficacy against emergence of drug resistance till date.

Graphical abstract

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