Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer

Human papillomavirus (HPV) is associated with a subset of head and neck squamous cell carcinomas (HNSCC) [1], with a strong association with cancers of the oropharynx (OPC), including cancers of the tonsils and base of tongue [2]. It is now estimated that HPV type 16 is associated with 65–80% of OPC [3,4] and incidence rates of HPV-related OPC are rapidly rising [5].

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