The Liver as a Hub in Thermogenesis

Publication date: 5 September 2017
Source:Cell Metabolism, Volume 26, Issue 3
Author(s): Nada A. Abumrad
Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. (2017) demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.

Teaser

Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.


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