Asthma predisposition and respiratory syncytial virus infection modulate transient receptor potential vanilloid 1 function in children's airways

The transient receptor potential vanilloid 1 (TRPV1) channel belongs to a family of proteins originally characterized in neuronal cells as a Ca2+-permeable, nonselective cation channels that sense physical and chemical stimuli such as noxious heat (>43°C), pH (<6.5 at 37°C), and vanilloid compounds such as capsaicin.1 TRPV1 has been shown to be expressed and functional in adult human bronchial epithelial (HBE) cells and to play a role in airway disease through increased mucus production,2 stimulation of cough reflex,3 airway smooth muscle contraction,4 and increased vascular permeability.

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