Margin evaluation is performed to assess the adequacy of tumor removal [1]. One of the quality initiatives introduced by the American Head and Neck Society deals with the management of patients with oral squamous cell carcinoma (SCC) extending to margins [2]. There are two major approaches to the sampling of margins [3–7]. In the specimen-driven approach, margin clearance is assessed from en bloc resection specimens. Studies have shown that the most relevant margins are those derived from the resection specimen [8–16].
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