P291 Heterozygous TACI mutation in patient with recurrent macrophage activation syndrome and systemic JIA

Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is a TNF receptor involved in B cell homeostasis, isotype switching, and innate immunity. PLCG2 encodes phospholipase CY2 (PLCY2), which catalyzes formation of secondary messengers for immune cell signaling.

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