Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy

Salivary duct carcinoma (SDC) was originally described by Kleinsasser and colleagues in 1968 as a salivary malignancy that histologically resembles ductal carcinoma of the breast [1]. It occurs more commonly in the parotid gland than in the submandibular or minor salivary glands [2–6]. SDC has a propensity to metastasize early to regional lymph nodes and distant sites, as well as a high rate of recurrence [3–5,7–12]. The mainstay of therapy includes surgery and radiation; use of systemic therapy has been explored in some case series and small clinical trials [9,13,14].

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