The incidence of oropharyngeal squamous cell carcinomas (OPSCCs) is increasing in the Western world [1–3]. The increase is primarily driven by increasing numbers of human papillomavirus positive (HPV+) OPSCCs [1–3]. The subgroup of patients with HPV+ OPSCC has markedly better overall and progression-free survival than HPV-negative (HPV−) patients [4].
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