What Ignites UCP1?

Publication date: 7 November 2017
Source:Cell Metabolism, Volume 26, Issue 5
Author(s): Barbara Cannon, Jan Nedergaard
We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.

Teaser

We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.


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