Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane

Publication date: 17 January 2018
Source:Polymer, Volume 135
Author(s): Koushik Dutta, Beauty Das, Jonathan Tersur Orasugh, Dipankar Mondal, Arpita Adhikari, Dipak Rana, Rajdeb Banerjee, Roshnara Mishra, Sumit Kar, Dipankar Chattopadhyay
The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively.

Graphical abstract

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