Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all malignancies worldwide [1]. Due to a high rate of local invasion and recurrence, the overall survival rate of OSCC patients has failed to substantially rise over the last decade [2]. Especially, locally advanced OSCC remains refractory and lethal in more than 50% cases [1]. Distant metastases are rarely found on initial presentation; therefore, locoregional disease control and the elucidation of the mechanism underlying OSCC invasion are critical to improving the survival rate of OSCC patients [3].

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