Enzyme targeting strategies and the prevention and treatment of cancer: implications for cancer therapy

Publication date: Available online 14 December 2017
Source:Seminars in Cancer Biology
Author(s): Mohammad Hassan Baig, Mohd Adil, Rosina Khan, Surendar Dhadi, Khurshid Ahmad, Gulam Rabbani, Tufail Bashir, Mohammad Azhar Imran, Fohad Mabood Husain, Eun Ju Lee, Mohammad Amjad Kamal, Inho Choi
Extensive growth of cancer in man is a major cause of death. Numerous studies are being conducted to improve the early diagnosis, prevention, and treatment of cancer, and recent technological advancements in medical science and research indicate molecular target therapy holds much promise. In the past, therapeutic and diagnostic targeting of non-glycolytic and glycolytic enzymes in cancer have been successful, and discoveries of biomarker enzymes in cancer hold promise for therapeutic treatments. In this review, we discuss the roles of several cancer-associated enzymes that could potentially act as therapeutic targets, and place special focus on glycolytic and non-glycolytic enzymes. This review indicates that the targeting of metabolic signaling offers a promising means of developing novel anti-cancer therapies.



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