Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development

Publication date: Available online 26 December 2017
Source:Microbes and Infection
Author(s): Leanne M. Low, Danielle I. Stanisic, Michael F. Good
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.



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