Fighting Resilient Cancers with Iron

Publication date: Available online 7 December 2017
Source:Trends in Cell Biology
Author(s): Jonathan J. Chen, Lorenzo Galluzzi
Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.



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