Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer

The estimated annual incidence of oral squamous cell carcinoma (OSCC) is approximately 275,000 new cases worldwide. OSCC is the eighth most prevalent cancer in the world [1]. In Taiwan, OSCC ranks fifth among the predominant cancers for both sexes and accounts for the fourth most common cancer for males [2]. Development of recurrent cancer and second primary cancer is one of the major causes of the poor 5-year overall survival of OSCC patients [3]. Therefore, it is crucial to find a biomarker that can predict the progression, recurrence, and prognosis of OSCC at its earliest stage.

http://ift.tt/2kBhgzq