Linking Hedgehog, Translation, and mTORC1 in Medulloblastoma

Publication date: 18 December 2017
Source:Developmental Cell, Volume 43, Issue 6
Author(s): Frédéric Charron
In this issue of Developmental Cell, Wu et al. (2017) report that mTORC1-dependent mRNA translation is required for Hedgehog signaling. They show that this process is essential for proliferation of cerebellum granule neuron precursor cells in response to Hedgehog signaling and for the formation of medulloblastoma, a cerebellum brain tumor.

Teaser

In this issue of Developmental Cell, Wu et al. (2017) report that mTORC1-dependent mRNA translation is required for Hedgehog signaling. They show that this process is essential for proliferation of cerebellum granule neuron precursor cells in response to Hedgehog signaling and for the formation of medulloblastoma, a cerebellum brain tumor.


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