Oncogenic DNA viruses found in salivary gland tumors

Salivary gland tumors (SGTs) are rare, extremely complex entities posing a major challenge for both pathologists and clinicians [1,2]. Despite intensive research beginning in the early '90, the etiology of SGTs is still unclear [3]. Several human DNA viruses, including human papillomaviruses (HPVs), herpes viruses such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV), and polyomaviruses, have been implicated in a wide variety of tumors, and the majority of these can be detected in saliva samples [4–7].

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