Plasmodium Peekaboo: PK4 Mediates Parasite Latency

Publication date: 13 December 2017
Source:Cell Host & Microbe, Volume 22, Issue 6
Author(s): Edward Rea, Anthony A. Holder, Rita Tewari
In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

Teaser

In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.


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