Versatile Scaffold: Extrajunctional Roles for α-Catenin

Publication date: 20 November 2017
Source:Developmental Cell, Volume 43, Issue 4
Author(s): Srikanth Budnar, Alpha S. Yap
α-catenin is a scaffolding molecule that can bind F-actin and other cytoskeletal proteins. It is best known for its contribution to cell-cell adhesion. In this issue of Developmental Cell, Vassilev et al. (2017) identify an extrajunctional pool of α-catenin that regulates RhoA signaling and controls directional migration of single cells.

Teaser

α-catenin is a scaffolding molecule that can bind F-actin and other cytoskeletal proteins. It is best known for its contribution to cell-cell adhesion. In this issue of Developmental Cell, Vassilev et al. (2017) identify an extrajunctional pool of α-catenin that regulates RhoA signaling and controls directional migration of single cells.


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