Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy's history, efficacy, and application in humans.

Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy's history, efficacy, and application in humans.

Int J Hyperthermia. 2018 Jan 21;:1-36

Authors: Mahmoudi K, Bouras A, Bozec D, Ivkov R, Hadjipanayis C

Abstract
Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer treatment have been studied for decades. Techniques used to achieve a localized hyperthermic effect include radiofrequency, ultrasound, microwave, laser, and magnetic nanoparticles (MNPs). The use of MNPs for therapeutic hyperthermia generation is known as magnetic hyperthermia therapy (MHT) and was first attempted as a cancer therapy in 1957. However, despite more recent advancements, MHT has still not become part of the standard of care for cancer treatment. Certain challenges, such as accurate thermometry within the tumor mass and precise tumor heating, preclude its widespread application as a treatment modality for cancer. MHT is especially attractive for the treatment of glioblastoma (GBM), the most common and aggressive primary brain cancer in adults, which has no cure. In this review, the application of MHT as a therapeutic modality for GBM will be discussed. Its therapeutic efficacy, technical details, and major experimental and clinical findings will be reviewed and analyzed. Finally, current limitations, areas of improvement, and future directions will be discussed in depth.

PMID: 29353516 [PubMed - as supplied by publisher]

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