Smoothened Sensor Places Sodium and Sterols Center Stage

Publication date: 8 January 2018
Source:Developmental Cell, Volume 44, Issue 1
Author(s): Robert Blassberg, James Briscoe
Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.

Teaser

Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.


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