TNFR2: The new Treg switch?

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TNFR2: The new Treg switch?

Oncoimmunology. 2017;7(1):e1373236

Authors: Cohen JL, Wood KJ

Abstract
Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. This identified the TNF/TNR2 pathway as a swith and as a new target for immune checkpoint therapy to modulate the immune regulation in this clinical setting.

PMID: 29296530 [PubMed]

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