Usefulness of the cllflow score.

Usefulness of the cllflow score.

Cytometry B Clin Cytom. 2018 Jan 06;:

Authors: Sorigue M, Franch-Sarto M, Sarrate E, Junca J

Abstract
BACKGROUND: The CLLflow score was recently suggested as an improvement over the Moreau score for the diagnosis and classification of B-cell lymphoproliferative disorders (B-LPD).
METHODS: We determined the CLLflow score in peripheral blood or bone marrow of a series of cases with an inconclusive immunophenotype, including samples with a Moreau score of 3 (n=52) and CD5-positive with a score of 2 (n=38). As controls, B-LPD with a Moreau score of 0-1 (n=95), CD5-negative score 2 (n=24) and score 4-5 (i.e., chronic lymphocytic leukemia [CLL], n=166) were included.
RESULTS: The CLLflow score was positive (suggestive of CLL) in all CLL cases and negative in all Moreau score <2, regardless of CD200-positivity, which occurred in 31% (29/95) of cases. The CLLflow score was positive in 71%, 29% and 8% of samples with a Moreau score 3, CD5-positive score 2 and CD5-negative score 2, respectively.
DISCUSSION: Our results suggest that the CLLflow is useful in the differential diagnosis of cases with inconclusive immunophenotype. This article is protected by copyright. All rights reserved.

PMID: 29316199 [PubMed - as supplied by publisher]

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