Characterization of salivary gland tumors with diffusion tensor imaging.

Characterization of salivary gland tumors with diffusion tensor imaging.

Dentomaxillofac Radiol. 2018 Feb 07;:20170343

Authors: Abdel Razek AAK

Abstract
PURPOSE: To characterize salivary glands tumors with diffusion tensor imaging.
METHODS: This study was conducted upon 53 patients (aged 18-81 years: mean 37 years) with salivary gland tumors that underwent diffusion tensor imaging was obtained using a single-shot echo-planar imaging sequence with parallel imaging at 1.5 tesla scanner. Forty-eight slices were obtained, with a thickness of 2.5 mm, with no gap and the total scan duration was 7-8 min. The fractional anisotropy (FA) and the mean diffusivity (MD) value of the salivary gland tumors was calculated and correlated with pathological findings. Image analysis was performed by one radiologist. The receiver operating characteristic curve was drawn to detect the cutoff point of FA and MD used to characterize salivary gland tumors.
RESULTS: The mean FA and MD of malignant salivary gland tumors (n = 17) (0.41 ± 0.07 and0.89 ± 0.15×10-3 mm2/s) was significantly different (p = 0.001) than that of benign tumors (n = 36) (0.19 ± 0.07 and1.28 ± 0.42×10-3 mm2/s) respectively. Combined FA and MD used to differentiate malignant from benign tumors has an area under the curve (AUC) of 0.974, and an accuracy of 86%. There was a significant difference in FA between Warthin tumors and malignant tumors (p = 0.001). Selection FA of 0.35 to differentiate malignant tumors from Warthin tumors revealed AUC of 0.878 and an accuracy of 80%. There was a significant difference in FA and MD of malignant tumors and pleomorphic adenomas (p = 0.001). Combined FA and MD used to differentiate malignant tumors from pleomorphic adenomas revealed AUC of 0.993, and an accuracy of 93%. There was a significant difference in FA and MD of Warthin tumors and pleomorphic adenomas (p = 0.001). Combined FA and MD used to differentiate Warthin tumors from pleomorphic adenomas revealed AUC of 0.978, and an accuracy of 86%.
CONCLUSIONS: Diffusion-weighed imaging is a promising non-invasive method and it may be useful for the characterization and differentiation of benign and malignant salivary gland tumors.

PMID: 29412748 [PubMed - as supplied by publisher]

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