Inadequate Production of H2 by Gut Microbiota and Parkinson Disease

Publication date: Available online 22 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Sergej M. Ostojic
Dysbiosis of the gut flora accompanies Parkinson disease (PD), yet no specific cause–effect link has been identified so far. The gut microbiota produce molecular hydrogen (H2), a ubiquitous molecule recently recognized as a biologically active gas with antioxidant, antiapoptotic, anti-inflammatory, cytoprotective, and signaling properties. Here, we discuss an idea that an impaired production of endogenous H2 by intestinal microbiota might play a role in PD pathogenesis, with supplemental H2 debated as a possible therapy for this progressive neurodegenerative disease.



http://ift.tt/2sPF1Yk