Squeezing Flux Out of Fat

Publication date: Available online 4 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Alba Gonzalez-Franquesa, Mary-Elizabeth Patti
Merging transcriptomics or metabolomics data remains insufficient for metabolic flux estimation. Ramirez et al. integrate a genome-scale metabolic model with extracellular flux data to predict and validate metabolic differences between white and brown adipose tissue. This method allows both metabolic phenotyping and the identification of potential therapeutic targets for obesity.



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